Flexeril (cyclobenzaprine) is primarily used as a muscle relaxant to relieve muscle spasms associated with acute, painful musculoskeletal conditions, such as strains, sprains, or other muscle injuries, usually alongside rest and physical therapy[1][2][3][4][5].
It is intended for short-term use, generally not exceeding 2–3 weeks, as its effectiveness for prolonged periods has not been established and most musculoskeletal injuries of this type are self-limiting[1][2].
Flexeril works by acting on the central nervous system (brainstem) to reduce excessive muscle activity, thereby alleviating pain and improving range of motion without affecting overall muscle function[1][3].
It is not indicated for the treatment of muscle spasms due to neurological conditions such as cerebral palsy or for spasticity associated with cerebral or spinal cord disorders[1][2].
Occasionally, it may be considered for off-label uses such as treatment of certain pain syndromes (e.g., myofascial pain due to temporomandibular disorders) or fibromyalgia, but such uses are not FDA-approved and evidence for benefit in these contexts is limited[1][2].