Diltiazem is primarily used to treat high blood pressure (hypertension) and prevent chest pain caused by angina[1][2][3][4][5][6]. It works by relaxing blood vessels, making it easier for the heart to pump blood and reducing its workload[2][3][6]. This mechanism lowers blood pressure and improves the supply of blood and oxygen to the heart[5].
- High blood pressure (hypertension) — Taking diltiazem helps prevent coronary heart disease, heart attacks, and strokes by controlling elevated blood pressure[1][2][3][5].
- Angina (chest pain) — Diltiazem reduces episodes of chest pain by dilating coronary arteries and lowering myocardial oxygen demand[2][3][5]. It is effective both for chronic stable angina and angina caused by coronary artery spasm[4].
- Raynaud’s phenomenon — It may be used to reduce the frequency of attacks in patients with this vascular condition[1].
- Anal fissures — Diltiazem cream or ointment is sometimes prescribed to promote healing of anal fissures[1][3].
- Atrial arrhythmias (off-label use) — Diltiazem can help manage certain heart rhythm problems, such as atrial fibrillation and flutter[3].
Diltiazem is available by prescription in oral tablet or capsule forms for cardiovascular conditions, and as topical preparations for anal fissures[1]
References
- [1] About diltiazem – NHS
- [2] Diltiazem: MedlinePlus Drug Information
- [3] Diltiazem: Uses, Interactions, Mechanism of Action | DrugBank Online
- [4] Cardizem (diltiazem hydrochloride) tablets – accessdata.fda.gov
- [5] Diltiazem (oral route) – Side effects & dosage – Mayo Clinic
- [6] Diltiazem: Uses & Side Effects – Cleveland Clinic