Sucralfate is primarily used to treat and prevent duodenal ulcers—ulcers that occur in the first part of the small intestine[2]. It is also used in the management of gastric ulcers and can be prescribed to prevent the return of ulcers after healing[1]. In addition, sucralfate can be used for other ulcer-related conditions as determined by a healthcare provider, including the treatment and prevention of ulcers in the stomach and to help manage symptoms of gastroesophageal reflux disease (GERD), gastritis, peptic ulcer disease, and stress ulcers[1].
Sucralfate works by forming a protective barrier or coating over the ulcer site. This barrier shields the ulcer from stomach acids and digestive enzymes, allowing it to heal more effectively[6]. The action of sucralfate is primarily localized to the stomach lining, with minimal absorption into the body[4].
Typical usage involves taking sucralfate as a tablet or liquid by mouth, most often on an empty stomach—either 1 hour before or 2 hours after meals[2]. Treatment duration for active duodenal ulcers is generally up to 8 weeks, and a lower maintenance dose may be used to prevent ulcer recurrence[4].