Mirtazapine is primarily used to treat major depressive disorder in adults[1][3][5]. It works by increasing levels of specific mood-enhancing chemicals, namely serotonin and noradrenaline, in the brain[3][6].
Besides its main use in depression, mirtazapine is sometimes prescribed “off-label” for other conditions such as:
- Insomnia, especially when associated with depression, as it can cause drowsiness and improve sleep quality[1][2][3].
- Anxiety disorders, including generalized anxiety disorder and panic disorder[1][3].
- Obsessive-compulsive disorder (OCD)[3].
- Appetite stimulation and weight gain, making it useful in cases of anorexia or unintentional weight loss, particularly in patients with advanced illness or cancer[1][2].
- Palliative care to relieve multiple symptoms such as mood disorders, poor appetite, and sleep issues in people with serious illness[2].
- Other potential off-label uses include treatment of pruritus (chronic itching), tension headaches, PTSD, and as adjunct therapy for certain substance abuse disorders[1][7].
Mirtazapine is typically prescribed as a tablet, a dissolvable tablet, or a liquid. It is usually taken once daily, most often at night because of its sedative effects[3].