Linzess is a prescription medication primarily used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults[1][5][7]. It is also approved for the treatment of functional constipation in children and adolescents aged 6 to 17 years[1].
Linzess contains the active ingredient linaclotide, which belongs to the drug class of guanylate cyclase-C (GC-C) agonists. Linaclotide acts locally in the intestine by activating GC-C receptors; this leads to increased secretion of intestinal fluids, softening the stool and promoting bowel movements. Additionally, activating these receptors can reduce abdominal pain associated with IBS-C[1][2][4][6].
The medication increases the levels of cyclic guanosine monophosphate (cGMP) inside the cells of the gut lining. This mechanism enhances fluid secretion and motility in the gut, helping to relieve symptoms of constipation and associated discomfort[2][3][4][6][8].
The main approved uses of Linzess are:
- Treatment of irritable bowel syndrome with constipation (IBS-C) in adults
- Treatment of chronic idiopathic constipation (CIC) in adults
- Treatment of functional constipation (FC) in children and adolescents 6 to 17 years old
References
- [1] Linzess: Uses, Dosage, Side Effects & Warnings – Drugs.com
- [2] Linzess (linaclotide) for the Treatment of Irritable Bowel …
- [3] Linzess (linaclotide) – Uses, Side Effects, and More – WebMD
- [4] Linaclotide (Linzess) for Irritable Bowel syndrome With …
- [5] LINZESS (linaclotide) capsules, for oral use – accessdata.fda.gov
- [6] Mechanism of Action in CIC | LINZESS® (linaclotide)
- [7] Linzess® (linaclotide): Treatment for IBS & Constipation
- [8] Linaclotide: Uses, Interactions, Mechanism of Action – DrugBank